You may be familiar with the four main DNA bases, but there’s more to our genes than ATGC, aka adenine, thymine, guanine, and cytosine. (Fun fact: The sci-fi movie Gattaca got its name by artfully combining those four letters.) At least 17 modified DNA letters (aka bases) have been found to date, including 5-formylcytosine (5fC), which was discovered in 2011. Technically a transitional form of cytosine that was corrected by repair enzymes, 5fC is an intermediate base that was found by researchers from the University of Cambridge to exist in tissue as a stable structure. |
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